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Q99ML2 
Protein names
 Non-receptor tyrosine-protein kinase TNK1
Kinase of embryonic stem cells
蛋白中文名
 非受体酪氨酸蛋白激酶TNK1
激酶of胚胎干细胞
 隐藏详细信息
Organism
 Mus musculus
Gene ID
 83813
Taxonomic identifier
 10090
Entry name
 TNK1_MOUSE
Gene names
 Tnk1
Kos1
Taxonomic lineage
 Eukaryota -> Metazoa -> Chordata -> Craniata -> Vertebrata -> Euteleostomi -> Mammalia -> Eutheria -> Euarchontoglires -> Glires -> Rodentia -> Sciurognathi -> Muroidea -> Muridae -> Murinae -> Mus -> Mus
Sequence length
 666
Sequence status
 Complete.
Protein existence
 Evidence at protein level
Function
 May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction (By similarity). Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway.
Subunit structure
 Interacts with the SH3 domain of PLCG1 via its Pro-rich domain (By similarity).
Subcellular location
 Membrane (By similarity). Cytoplasm.
Tissue specificity
 Expressed in whole embryo and all adult tissues examined including liver, kidney, heart, brain, skeletal muscle and intestine. Also detected in various myeloid- and lymphoid-derived cell lines.
Sequence similarities
 Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Contains 1 SH3 domain.
Post-translational modification
 Autophosphorylated on tyrosine residues.
Developmental stage
 Expression during embryogenesis increases between E7 and E11. Levels of expression subsequently decrease and reach a steady-state level by E17.
Disruption phenotype
 Mice develop spontaneous tumors, including lymphomas and carcinomas at high rates.
Catalytic activity
 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Cellular component
 Cytoplasm; Membrane
Coding sequence diversity
 Alternative splicing
[KW] Domain
 SH3 domain
Ligand
 ATP-binding; Nucleotide-binding
PTM
 Phosphoprotein
Molecular function
 Kinase; Transferase; Tyrosine-protein kinase
Technical term
 Complete proteome
Gene Ontology Biological process
 negative regulation of cell growth
negative regulation of Ras protein signal transduction
Gene Ontology Cellular component
 membrane
Gene Ontology Molecular function
 

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Non-receptor tyrosine-protein kinase TNK1 的相关产品:
公司名称产品编号产品名称包装价格详细信息
GenWay  查看代理商 18-001-30079 Non-receptor tyrosine-protein kinase TNK1 Antibody, Rabbit Polyclonal Antibody
 非受体酪氨酸蛋白激酶TNK1 yabo狗亚体育, 兔Polyclonalyabo狗亚体育
 0.1 mg $200.00
GenWay  查看代理商 18-511-244385 Rabbit anti Mouse Kos 1 Antibody, Rabbit Polyclonal Antibody
 兔抗小鼠Kos 1 yabo狗亚体育, 兔Polyclonalyabo狗亚体育
 0.1 mg $305.00
Thermo Fisher  查看代理商 PA1-4332 Anti-Kos1 Polyclonal Antibody
 Anti-Kos1 Polyclonalyabo狗亚体育
 100 μg 
Thermo Fisher  查看代理商 PA1-46255 Anti-Kos1 Polyclonal Antibody
 Anti-Kos1 Polyclonalyabo狗亚体育
 100 μl 
Abnova  查看代理商 PAB1064 Tnk1 polyclonal antibody
 Tnk1 polyclonalyabo狗亚体育
 100 ug $298.00

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