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Q15583?
Protein names
?Homeobox protein TGIF1
5'-TG-3'-interacting factor 1
蛋白中文名
?同源框蛋白TGIF1
5'-TG-3'-interacting因子 1
?隐藏详细信息
Organism
?Homo sapiens
Gene ID
?7050
Taxonomic identifier
?9606
Entry name
?TGIF1_HUMAN
Gene names
?TGIF1
TGIF
Taxonomic lineage
?Eukaryota -> Metazoa -> Chordata -> Craniata -> Vertebrata -> Euteleostomi -> Mammalia -> Eutheria -> Euarchontoglires -> Primates -> Haplorrhini -> Catarrhini -> Hominidae -> Homo
Sequence length
?401
Sequence status
?Complete.
Protein existence
?Evidence at protein level
Function
?Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Subunit structure
?Interacts with CTBP, SMAD2, SMAD3 and HDAC1.
Subcellular location
?Nucleus.
Sequence similarities
?Belongs to the TALE/TGIF homeobox family.

Contains 1 homeobox DNA-binding domain.
Involvement in disease
?Defects in TGIF1 are the cause of holoprosencephaly type 4 (HPE4) [MIM:142946]. Holoprosencephaly (HPE) [MIM:236100] is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
Biological process
?Transcription; Transcription regulation
Cellular component
?Nucleus
Coding sequence diversity
?Alternative splicing; Polymorphism
[KW] Domain
?Homeobox
Ligand
?DNA-binding
Molecular function
?Repressor
Technical term
?Complete proteome
Disease
?Disease mutation; Holoprosencephaly
Gene Ontology Biological process
?negative regulation of transcription from RNA polymerase II promoter
Gene Ontology Cellular component
?nucleus
Gene Ontology Molecular function
?sequence-specific DNA binding transcription factor activity
sequence-specific DNA binding

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Homeobox protein TGIF1 的相关产品:
公司名称产品编号产品名称包装价格详细信息
GenWay? 查看代理商?10-288-21970F?5'-TG-3'-interacting factor recombinant protein
?5'-TG-3'-interacting因子重组蛋白
?1 mg?$2500.00
GenWay? 查看代理商?20-372-60287?TGFB-induced factor (TALE family homeobox) Antibody, Mouse Monoclonal Antibody
?TGFB-诱导因子 (TALE家族同源框) yabo狗亚体育, 小鼠单克隆yabo狗亚体育
?0.1 mg?$350.00
GenWay? 查看代理商?20-203-420487?TGIF (C-term) Antibody, Rabbit Monoclonal Antibody
?TGIF (C-term) yabo狗亚体育, 兔单克隆yabo狗亚体育
?0.1 ml?$280.00
Thermo Fisher? 查看代理商?PA5-14151?Anti-TGIF Polyclonal Antibody
?Anti-TGIF Polyclonalyabo狗亚体育
?100 μg?
Abnova? 查看代理商?H00007050-R01?TGIF Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00007050-R01?TGIF Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00007050-R02?TGIF Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00007050-R02?TGIF Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00007050-R03?TGIF Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00007050-R03?TGIF Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00007050-R04?TGIF Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00007050-R04?TGIF Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00007050-R05?TGIF Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00007050-R05?TGIF Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00007050-R06?TGIF Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00007050-R06?TGIF Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00007050-R07?TGIF Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00007050-R07?TGIF Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00007050-R08?TGIF Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00007050-R08?TGIF Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00007050-P01?TGIF Recombinant Protein (P01)
?TGIF重组蛋白 (P01)
?10 ug?$290.00
Abnova? 查看代理商?H00007050-P01?TGIF Recombinant Protein (P01)
?TGIF重组蛋白 (P01)
?25 ug?$440.00
Abnova? 查看代理商?H00007050-Q01?TGIF Recombinant Protein (Q01)
?TGIF重组蛋白 (Q01)
?10 ug?$290.00
Abnova? 查看代理商?H00007050-Q01?TGIF Recombinant Protein (Q01)
?TGIF重组蛋白 (Q01)
?25 ug?$440.00
Abnova? 查看代理商??TGIF monoclonal antibody (M01), clone 1D12
?TGIF单克隆yabo狗亚体育 (M01), 克隆 1D12
?100 ug?$298.00
Abnova? 查看代理商?H00007050-A01?TGIF polyclonal antibody (A01)
?TGIF polyclonalyabo狗亚体育 (A01)
?50 uL?$206.00
Abnova? 查看代理商?PAB2851?TGIF1 polyclonal antibody
?TGIF1 polyclonalyabo狗亚体育
?100 ug?$298.00
Abgent? 查看代理商?AJ1766a?TGIF Antibody (C-term)
?TGIFyabo狗亚体育 (C-term)
??
Abgent? 查看代理商?AP7279c?TGIF Antibody (Center L223)
?TGIFyabo狗亚体育 (Center L223)
??
Abgent? 查看代理商?RI15301?TGIF1 predesign siRNA??
Abcam? 查看代理商?ab65179?TGIF antibody
?TGIFyabo狗亚体育
??
Abcam? 查看代理商?ab50884?TGIF antibody [946C1a]
?TGIFyabo狗亚体育 [946C1a]
??
Abcam? 查看代理商?ab52955?TGIF antibody [EP637Y]
?TGIFyabo狗亚体育 [EP637Y]
??
Novus? 查看代理商?NB110-57618?TGIF Antibody
?TGIFyabo狗亚体育
??
Novus? 查看代理商?30590002?TGIF Antibody
?TGIFyabo狗亚体育
??
Novus? 查看代理商?H00007050-A01?TGIF Antibody
?TGIFyabo狗亚体育
??
Novus? 查看代理商?H00007050-M01?TGIF Antibody
?TGIFyabo狗亚体育
??
Novus? 查看代理商?H00007050-P01?TGIF Recombinant Protein
?TGIF重组蛋白
??
Novus? 查看代理商?H00007050-Q01?TGIF Partial Recombinant Protein
?TGIF Partial重组蛋白
??
Novus? 查看代理商?NBL1-16862?TGIF Lysate??
Novus? 查看代理商?NBL1-16861?TGIF Lysate??
Novus? 查看代理商?NBL1-16863?TGIF Lysate??
Novus? 查看代理商?NBL1-16860?TGIF Lysate??
Novus? 查看代理商?H00007050-R02?TGIF RNAi??
Novus? 查看代理商?H00007050-R01?TGIF RNAi??
Novus? 查看代理商?H00007050-R05?TGIF RNAi??
Novus? 查看代理商?H00007050-R03?TGIF RNAi??
Novus? 查看代理商?H00007050-R08?TGIF RNAi??
Epitomics? 查看代理商?1916-1?TGIF (C-term) antibody RabMAb
?TGIF (C-term) yabo狗亚体育 RabMAb
??
Avivasysbio? 查看代理商?ARP51343_P050?TGIF1 (TGFB-induced factor homeobox 1) Antibody (against the C terminal of TGIF1)
?TGIF1 (TGFB-诱导因子同源框 1) yabo狗亚体育 (抗the C末端of TGIF1)
??
Avivasysbio? 查看代理商?AAPS23608?TGIF1 (TGFB-induced factor homeobox 1) Blocking Peptide (the C terminal of protein)
?TGIF1 (TGFB-诱导因子同源框 1) Blocking肽 (the C末端of蛋白)
??

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