Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Interacts with CTBP, SMAD2, SMAD3 and HDAC1.
Belongs to the TALE/TGIF homeobox family.
Contains 1 homeobox DNA-binding domain.
Involvement in disease
Defects in TGIF1 are the cause of holoprosencephaly type 4 (HPE4) [MIM:142946]. Holoprosencephaly (HPE) [MIM:236100] is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
Transcription; Transcription regulation
Coding sequence diversity
Alternative splicing; Polymorphism
Disease mutation; Holoprosencephaly
Gene Ontology Biological process
negative regulation of transcription from RNA polymerase II promoter
Gene Ontology Cellular component
Gene Ontology Molecular function
sequence-specific DNA binding transcription factor activity sequence-specific DNA binding