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Q13085?
Protein names
?Acetyl-CoA carboxylase 1
ACC1
ACC-alpha
Biotin carboxylase
蛋白中文名
?乙酰辅酶A羧化酶 1
生物素羧化酶
?隐藏详细信息
Organism
?Homo sapiens
Gene ID
?31
Taxonomic identifier
?9606
Entry name
?ACACA_HUMAN
Gene names
?ACACA
ACAC, ACC1, ACCA
Taxonomic lineage
?Eukaryota -> Metazoa -> Chordata -> Craniata -> Vertebrata -> Euteleostomi -> Mammalia -> Eutheria -> Euarchontoglires -> Primates -> Haplorrhini -> Catarrhini -> Hominidae -> Homo
Sequence length
?2346
Sequence status
?Complete.
Protein existence
?Evidence at protein level
Function
?Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Subunit structure
?Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
Subcellular location
?Cytoplasm.
Tissue specificity
?Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Sequence similarities
?Contains 1 ATP-grasp domain.

Contains 1 biotin carboxylation domain.

Contains 1 biotinyl-binding domain.

Contains 1 carboxyltransferase domain.
Involvement in disease
?Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.
Post-translational modification
?Phosphorylation on Ser-1263 is required for interaction with BRCA1.
Pathway
?Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Enzyme regulation
?By phosphorylation (By similarity). Activity is increased by oligomerization. Citrate and MID1IP1 promote oligomerization.
Catalytic activity
?ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.

ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein].
Cofactor
?Biotin.

Binds 2 manganese ions per subunit.
Biological process
?Fatty acid biosynthesis; Lipid synthesis
Cellular component
?Cytoplasm
Coding sequence diversity
?Alternative promoter usage; Polymorphism
Ligand
?ATP-binding; Biotin; Manganese; Metal-binding; Nucleotide-binding
PTM
?Acetylation; Phosphoprotein
Molecular function
?Ligase
Technical term
?3D-structure; Allosteric enzyme; Complete proteome; Direct protein sequencing; Multifunctional enzyme
Gene Ontology Biological process
?acetyl-CoA metabolic process
fatty acid biosynthetic process
positive regulation of cellular metabolic process
Gene Ontology Cellular component
?
Gene Ontology Molecular function
?protein binding
metal ion binding

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Acetyl-CoA carboxylase 1 的相关产品:
公司名称产品编号产品名称包装价格详细信息
GenWay? 查看代理商?20-203-420372?Acetyl CoA Carboxylase 1 (ACC1) Antibody, Rabbit Monoclonal Antibody
?乙酰辅酶A羧化酶 1 (ACC1) yabo狗亚体育, 兔单克隆yabo狗亚体育
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Abnova? 查看代理商?H00000031-R01?ACACA Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00000031-R01?ACACA Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00000031-R02?ACACA Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00000031-R02?ACACA Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00000031-R03?ACACA Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00000031-R03?ACACA Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00000031-R04?ACACA Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00000031-R04?ACACA Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00000031-R05?ACACA Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00000031-R05?ACACA Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00000031-R06?ACACA Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00000031-R06?ACACA Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00000031-R07?ACACA Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00000031-R07?ACACA Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00000031-Q01?ACACA Recombinant Protein (Q01)
?ACACA重组蛋白 (Q01)
?10 ug?$290.00
Abnova? 查看代理商?H00000031-Q01?ACACA Recombinant Protein (Q01)
?ACACA重组蛋白 (Q01)
?25 ug?$440.00
Abnova? 查看代理商??ACACA monoclonal antibody (M01), clone 6H5
?ACACA单克隆yabo狗亚体育 (M01), 克隆 6H5
?100 ug?$298.00
Abnova? 查看代理商?PAB17278?ACACA polyclonal antibody
?ACACA polyclonalyabo狗亚体育
?100 ug?$298.00
Abnova? 查看代理商?PAB17282?ACACA polyclonal antibody
?ACACA polyclonalyabo狗亚体育
?100 ug?$298.00
Abgent? 查看代理商?AT1018a?ACACA Antibody (monoclonal) (M01)
?ACACAyabo狗亚体育 (单克隆) (M01)
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Abgent? 查看代理商?AJ1010a?Acetyl-CoA1 (ACC1) Antibody
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Abgent? 查看代理商?RI10039?ACACA predesign siRNA??
Abcam? 查看代理商?ab53688?Acetyl Coenzyme A Carboxylase (phospho S80) antibody
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Abcam? 查看代理商?ab55177?Acetyl Coenzyme A Carboxylase (phospho S80) antibody
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Abcam? 查看代理商?ab80052?Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody
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Abcam? 查看代理商?ab72045?Acetyl Coenzyme A carboxylase alpha antibody
?乙酰辅酶A羧化酶alphayabo狗亚体育
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Abcam? 查看代理商?ab72046?Acetyl Coenzyme A carboxylase alpha antibody
?乙酰辅酶A羧化酶alphayabo狗亚体育
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Abcam? 查看代理商?ab78274?Acetyl Coenzyme A carboxylase alpha antibody [EP687Y]
?乙酰辅酶A羧化酶alphayabo狗亚体育 [EP687Y]
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Abcam? 查看代理商?ab63485?Acetyl Coenzyme A Carboxylase antibody
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Abcam? 查看代理商?ab63531?Acetyl Coenzyme A Carboxylase antibody
?乙酰辅酶A羧化酶yabo狗亚体育
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Abcam? 查看代理商?ab45174?Acetyl Coenzyme A Carboxylase antibody [EP687Y]
?乙酰辅酶A羧化酶yabo狗亚体育 [EP687Y]
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Novus? 查看代理商?NB110-55440?Acetyl Coenzyme A Carboxylase Alpha Antibody
?乙酰辅酶A羧化酶Alphayabo狗亚体育
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Novus? 查看代理商?NB100-92011?Acetyl Coenzyme A Carboxylase Alpha Antibody
?乙酰辅酶A羧化酶Alphayabo狗亚体育
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Novus? 查看代理商?NB100-55246?Acetyl Coenzyme A Carboxylase Alpha Antibody
?乙酰辅酶A羧化酶Alphayabo狗亚体育
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Novus? 查看代理商?NB100-55247?Acetyl Coenzyme A Carboxylase Alpha Antibody
?乙酰辅酶A羧化酶Alphayabo狗亚体育
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Novus? 查看代理商?NBP1-40444?Acetyl Coenzyme A Carboxylase Alpha Antibody
?乙酰辅酶A羧化酶Alphayabo狗亚体育
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Novus? 查看代理商?H00000031-Q01?Acetyl Coenzyme A Carboxylase Alpha Partial Recombinant Protein
?乙酰辅酶A羧化酶Alpha Partial重组蛋白
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Novus? 查看代理商?H00000031-R03?Acetyl Coenzyme A Carboxylase Alpha RNAi
?乙酰辅酶A羧化酶Alpha RNAi
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Novus? 查看代理商?H00000031-R02?Acetyl Coenzyme A Carboxylase Alpha RNAi
?乙酰辅酶A羧化酶Alpha RNAi
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Novus? 查看代理商?H00000031-R05?Acetyl Coenzyme A Carboxylase Alpha RNAi
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Novus? 查看代理商?H00000031-R04?Acetyl Coenzyme A Carboxylase Alpha RNAi
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Novus? 查看代理商?H00000031-R06?Acetyl Coenzyme A Carboxylase Alpha RNAi
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Epitomics? 查看代理商?3495-1?Acetyl CoA Carboxylase 1 (ACC1) antibody RabMAb
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Epitomics? 查看代理商?1768-1?Acetyl CoA Carboxylase 1 (ACC1) antibody RabMAb
?乙酰辅酶A羧化酶 1 (ACC1) yabo狗亚体育 RabMAb
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Epitomics? 查看代理商?2327-1?Acetyl CoA Carboxylase 1 (ACC1) Phos (pS79) antibody RabMAb
?乙酰辅酶A羧化酶 1 (ACC1) Phos (pS79) yabo狗亚体育 RabMAb
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Bethyl? 查看代理商?A300-986A?ACC1/ACC-alpha Antibody
?ACC1/ACC-alphayabo狗亚体育
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Bethyl? 查看代理商?A300-987A?ACC1/ACC-alpha Antibody
?ACC1/ACC-alphayabo狗亚体育
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Bethyl? 查看代理商?A310-320A?ACC1/ACC-alpha Antibody AbVantage
?ACC1/ACC-alphayabo狗亚体育AbVantage
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Bethyl? 查看代理商?BP300-986?ACC1/ACC-alpha Blocking Peptide
?ACC1/ACC-alpha Blocking肽
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Bethyl? 查看代理商?BP300-987?ACC1/ACC-alpha Blocking Peptide
?ACC1/ACC-alpha Blocking肽
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Bethyl? 查看代理商?A310-320A?ACC1/ACC-alpha Antibody AbVantage
?ACC1/ACC-alphayabo狗亚体育AbVantage
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assaybiotech? 查看代理商?A0405?ACC1 (Phospho-Ser80) Antibody
?ACC1 (Phospho-Ser80) yabo狗亚体育
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assaybiotech? 查看代理商?A0051?Acetyl-CoA Carboxylase (Phospho-Ser80) Antibody
?乙酰辅酶A羧化酶 (Phospho-Ser80) yabo狗亚体育
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assaybiotech? 查看代理商?B0405?ACC1 (Ab-80) Antibody
?ACC1 (Ab-80) yabo狗亚体育
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assaybiotech? 查看代理商?B0051?Acetyl-CoA Carboxylase (Ab-80) Antibody
?乙酰辅酶A羧化酶 (Ab-80) yabo狗亚体育
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