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P63261?
Protein names
?Actin, cytoplasmic 2
Gamma-actin
Actin, cytoplasmic 2, N-terminally processed
蛋白中文名
?肌动蛋白, 胞质 2
肌动蛋白, 胞质 2, N-terminally processed
?隐藏详细信息
Organism
?Homo sapiens
Gene ID
?71
Taxonomic identifier
?9606
Entry name
?ACTG_HUMAN
Gene names
?ACTG1
ACTB, ACTG
Taxonomic lineage
?Eukaryota -> Metazoa -> Chordata -> Craniata -> Vertebrata -> Euteleostomi -> Mammalia -> Eutheria -> Euarchontoglires -> Primates -> Haplorrhini -> Catarrhini -> Hominidae -> Homo
Sequence length
?375
Sequence status
?Complete.
Protein existence
?Evidence at protein level
Function
?Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit structure
?Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
Subcellular location
?Cytoplasm, cytoskeleton.
Miscellaneous
?In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Sequence similarities
?Belongs to the actin family.
Involvement in disease
?Defects in ACTG1 are the cause of deafness autosomal dominant type 20 (DFNA20) [MIM:604717]; also called autosomal dominant deafness type 26 (DFNA26). DFNA20 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Post-translational modification
?The methylhistidine determined by Bienvenut et al is assumed to be the tele-methylhistidine isomer by similarity to the mouse ortholog.
Cellular component
?Cytoplasm; Cytoskeleton
Coding sequence diversity
?Polymorphism
Ligand
?ATP-binding; Nucleotide-binding
PTM
?Acetylation; Methylation; Phosphoprotein
Technical term
?Complete proteome; Direct protein sequencing
Disease
?Deafness; Disease mutation; Non-syndromic deafness
Gene Ontology Biological process
?cellular component movement
axon guidance
blood coagulation
cell junction assembly
adherens junction organization
Gene Ontology Cellular component
?cytoskeleton
Gene Ontology Molecular function
?

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