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P62736?
Protein names
?Actin, aortic smooth muscle
Alpha-actin-2
Cell growth-inhibiting gene 46 protein
蛋白中文名
?肌动蛋白, aortic平滑肌
细胞生长抑制基因 46 蛋白
细胞生长抑制基因 46 蛋白质
细胞生长抑制基因 46 卵白
?隐藏详细信息
Organism
?Homo sapiens
Gene ID
?59
Taxonomic identifier
?9606
Entry name
?ACTA_HUMAN
Gene names
?ACTA2
ACTSA, ACTVS
GIG46
Taxonomic lineage
?Eukaryota -> Metazoa -> Chordata -> Craniata -> Vertebrata -> Euteleostomi -> Mammalia -> Eutheria -> Euarchontoglires -> Primates -> Haplorrhini -> Catarrhini -> Hominidae -> Homo
Sequence length
?377
Sequence status
?Complete.
Protein existence
?Evidence at protein level
Function
?Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit structure
?Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
Subcellular location
?Cytoplasm, cytoskeleton.
Miscellaneous
?In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

Defects in ACTA2 predispose patients to a variety of diffuse and diverse vascular diseases, premature onset coronary artery disease (CAD), premature ischemic strokes and Moyamoya disease (MMD).
Sequence similarities
?Belongs to the actin family.
Induction
?Up-regulated in response to enterovirus 71 (EV71) infection.
Involvement in disease
?Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
Cellular component
?Cytoplasm; Cytoskeleton
Coding sequence diversity
?Polymorphism
Ligand
?ATP-binding; Nucleotide-binding
PTM
?Acetylation; Methylation; Nitration; Phosphoprotein
Molecular function
?Muscle protein
Technical term
?Complete proteome
Disease
?Aortic aneurysm; Disease mutation
Gene Ontology Biological process
?response to virus
Gene Ontology Cellular component
?
Gene Ontology Molecular function
?

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Actin, aortic smooth muscle 的相关产品:
公司名称产品编号产品名称包装价格详细信息
Thermo Fisher? 查看代理商?MA1-12772?Anti-Smooth Muscle alpha Actin Monoclonal Antibody
?抗平滑肌alpha肌动蛋白单克隆yabo狗亚体育
?100 μg?
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Thermo Fisher? 查看代理商?MA1-33746?Anti-Skeletal Muscle Actin Monoclonal Antibody
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Thermo Fisher? 查看代理商?MA1-33748?Anti-Skeletal Muscle Actin Monoclonal Antibody
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Thermo Fisher? 查看代理商?MA1-33749?Anti-Skeletal Muscle Actin Monoclonal Antibody
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Thermo Fisher? 查看代理商?MA1-37028?Anti-Smooth Muscle Actin Monoclonal Antibody
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Thermo Fisher? 查看代理商?PA1-27447?Anti-ACTA2 Polyclonal Antibody
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?100 μg?
Thermo Fisher? 查看代理商?PA1-29549?Anti-Skeletal Muscle Actin Polyclonal Antibody
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Thermo Fisher? 查看代理商?PA1-37019?Anti-Skeletal Muscle Actin Polyclonal Antibody
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?7 ml?
Thermo Fisher? 查看代理商?PA1-37023?Anti-Smooth Muscle Actin Polyclonal Antibody
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?7 ml?
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Thermo Fisher? 查看代理商?PA5-12505?Anti-ACTC Polyclonal Antibody
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?100 μg?
Thermo Fisher? 查看代理商?PA5-12506?Anti-ACTC Polyclonal Antibody
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Abnova? 查看代理商?H00000059-R01?ACTA2 Pre-design Chimera RNAi?10 nmol?$220.00
Abnova? 查看代理商?H00000059-R01?ACTA2 Pre-design Chimera RNAi?20 nmol?$264.00
Abnova? 查看代理商?H00000059-P01?ACTA2 Recombinant Protein (P01)
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?10 ug?$290.00
Abnova? 查看代理商?H00000059-P01?ACTA2 Recombinant Protein (P01)
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?25 ug?$440.00
Abnova? 查看代理商?H00000059-B01P?ACTA2 purified MaxPab mouse polyclonal antibody (B01P)
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Abnova? 查看代理商??ACTA2 monoclonal antibody (M01), clone 1D11-2B9
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Abnova? 查看代理商??ACTA2 monoclonal antibody (M02), clone 4A8-2H3
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?100 ug?$298.00
Abnova? 查看代理商??ACTA2 monoclonal antibody, clone 1A4
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Abnova? 查看代理商?PAB11173?ACTA2 polyclonal antibody
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?100 uL?$298.00
Abnova? 查看代理商?PAB12649?ACTA2 polyclonal antibody
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Abgent? 查看代理商?AT1030a?ACTA2 Antibody (monoclonal) (M02)
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??
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Abcam? 查看代理商?ab49481?alpha smooth muscle Actin antibody [alpha sm-1] - Aminoterminal end
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Abcam? 查看代理商?ab28027?alpha smooth muscle Actin antibody [CGA7]
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Abcam? 查看代理商?ab32575?alpha smooth muscle Actin antibody [E184]
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Abcam? 查看代理商?ab40865?alpha smooth muscle Actin antibody [HUC1-1]
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Abcam? 查看代理商?ab46805?muscle Actin antibody [EP184E]
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Abcam? 查看代理商?ab838?muscle Actin antibody [HHF35], prediluted
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??
Novus? 查看代理商?NBP1-19535?Actin Alpha 2/3 Smooth Muscle Antibody
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Abbiotec? 查看代理商?252037?SMA Antibody
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Epitomics? 查看代理商?S0010?Alpha Smooth Muscle Actin antibody
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Bethyl? 查看代理商?A301-990A?Alpha Smooth Muscle Actin Antibody
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AbD? 查看代理商??MOUSE ANTI HUMAN ACTIN (AORTIC):Azide Free
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Spring Bioscience, Inc.? 查看代理商?E14340?Actin-Smooth Muscle
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Spring Bioscience, Inc.? 查看代理商?E2760?c-erbB-4/HER-4??

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