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P40394?
Protein names
?Alcohol dehydrogenase class 4 mu/sigma chain
Alcohol dehydrogenase class IV mu/sigma chain
Gastric alcohol dehydrogenase
Retinol dehydrogenase
蛋白中文名
?乙醇脱氢酶class 4 mu/sigma链
乙醇脱氢酶class IV mu/sigma链
胃乙醇脱氢酶
视黄醇脱氢酶
?隐藏详细信息
Organism
?Homo sapiens
Gene ID
?131
Taxonomic identifier
?9606
Entry name
?ADH7_HUMAN
Gene names
?ADH7
Taxonomic lineage
?Eukaryota -> Metazoa -> Chordata -> Craniata -> Vertebrata -> Euteleostomi -> Mammalia -> Eutheria -> Euarchontoglires -> Primates -> Haplorrhini -> Catarrhini -> Hominidae -> Homo
Sequence length
?386
Sequence status
?Complete.
Protein existence
?Evidence at protein level
Function
?Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
Subunit structure
?Homodimer.
Subcellular location
?Cytoplasm.
Tissue specificity
?Preferentially expressed in stomach.
Miscellaneous
?There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class- V: ADH6.
Sequence similarities
?Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
Caution
?It is uncertain whether Met-1 or Met-13 is the initiator.
Catalytic activity
?An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor
?Binds 2 zinc ions per subunit.
Cellular component
?Cytoplasm
Coding sequence diversity
?Polymorphism
Ligand
?Metal-binding; NAD; Zinc
Molecular function
?Oxidoreductase
Technical term
?3D-structure; Complete proteome; Direct protein sequencing
Gene Ontology Biological process
?xenobiotic metabolic process
response to bacterium
response to ethanol
Gene Ontology Cellular component
?
Gene Ontology Molecular function
?

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