This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Cell membrane; Multi-pass membrane protein.
Belongs to the G-protein coupled receptor 1 family.
Cell membrane; Membrane
Coding sequence diversity
Transmembrane; Transmembrane helix
Disulfide bond; Glycoprotein
Gene Ontology Biological process
G-protein signaling, coupled to cyclic nucleotide second messenger synaptic transmission