This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location
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Cell membrane; Multi-pass membrane protein.
Sequence similarities
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Belongs to the G-protein coupled receptor 1 family.
Cellular component
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Cell membrane; Membrane
Coding sequence diversity
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Polymorphism
[KW] Domain
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Transmembrane; Transmembrane helix
PTM
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Disulfide bond; Glycoprotein
Molecular function
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Receptor; Transducer
Technical term
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Complete proteome
Gene Ontology Biological process
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G-protein signaling, coupled to cyclic nucleotide second messenger synaptic transmission
