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P25098 
Protein names
 Beta-adrenergic receptor kinase 1
Beta-ARK-1
G-protein coupled receptor kinase 2
蛋白中文名
 Beta-肾上腺素能受体激酶 1
G蛋白偶联受体激酶 2
 隐藏详细信息
Organism
 Homo sapiens
Gene ID
 156
Taxonomic identifier
 9606
Entry name
 ARBK1_HUMAN
Gene names
 ADRBK1
BARK, BARK1, GRK2
Taxonomic lineage
 Eukaryota -> Metazoa -> Chordata -> Craniata -> Vertebrata -> Euteleostomi -> Mammalia -> Eutheria -> Euarchontoglires -> Primates -> Haplorrhini -> Catarrhini -> Hominidae -> Homo
Sequence length
 689
Sequence status
 Complete.
Protein existence
 Evidence at protein level
Function
 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Subunit structure
 Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1.
Tissue specificity
 Expressed in peripheral blood leukocytes.
Sequence similarities
 Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 PH domain.

Contains 1 protein kinase domain.

Contains 1 RGS domain.
Catalytic activity
 ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.
Coding sequence diversity
 Polymorphism
Ligand
 ATP-binding; Nucleotide-binding
PTM
 Acetylation; Phosphoprotein
Molecular function
 Kinase; Serine/threonine-protein kinase; Transferase
Technical term
 3D-structure; Complete proteome
Gene Ontology Biological process
 desensitization of G-protein coupled receptor protein signaling pathway
muscarinic acetylcholine receptor signaling pathway
peptidyl-serine phosphorylation
positive regulation of catecholamine secretion
Gene Ontology Cellular component
 
Gene Ontology Molecular function
 signal transducer activity

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