Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
Subunit structure
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Homodimer.
Subcellular location
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Cytoplasm.
Miscellaneous
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There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class- V: ADH6.
Sequence similarities
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Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Catalytic activity
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An alcohol + NAD(+) = an aldehyde or ketone + NADH.
